PATER

PATERNITY EVALUATION AND REPORT PROGRAM

This program is a self-contained product for preparation of formal paternity reports with many allied facilities. It works very naturally with DNA·VIEW for DNA types and also deals thoroughly with classical blood groups.

compatible with DNA·VIEW
user friendly

five minutes to create a paternity report from scratch
easy to update or revise a report

comprehensive on-line help, plus manual
interface to or substitute for patient accessioning
atypical scenarios like extra men/children, motherless(paper) (example)/maternity/immigration cases
calculation detail worksheet for program verification and validation
summary reports -- e.g. summarize cases by DA
modify gene frequencies and add races
cull gene frequencies from the data
separate report formats for inclusion, exclusion, or advisory-only opinion; and laboratory internal
avuncular index (Did a brother do it?) is included on the laboratory's report.

to mention just a few of PATER's capabilities.

Prices (including 1 year of maintenance, upgrade, support, and warranty)	inquire

Inquiries to: email contact
Charles Brenner home page

Shown here is the "inclusion" format to be sent to the client or lawyer.
The headings, footings, and choice of columns are user-configurable.
Other customization is available on request including other languages -- Deutsch, Portugues

PATERNITY REPORT
Long Island Laboratories
(800)551-1111

Tested Man: Reverend Mr. Dimmesdale (C) 1000-00036 Mother: Hester Prynne (C) 1000-00034 Child: Pearl 1000-00035 SUMMARY OF FINDINGS: Reverend Mr. Dimmesdale is not excluded as the father of Pearl. Combined paternity index = 27000000 Probability of paternity = 99.999996% (50% prior probability) T E S T OBSERVED PHENOTYPES CALCULATION OF PATERNITY INDEX Tested Paternity Nonpaternity Ratio Mother Child Man Assumed (X) Assumed (Y) (X/Y) PCR loci D8S1179 12 14 12 15 14 15 0.25 0.101 2.47 D21S11 30 30 30.2 29 30.2 0.5 0.0154 32.5 D7S820 8 12 12 12 0.5 0.0545 9.17 CSF1PO 12 12 14 10 14 0.5 0.0112 44.7 D3S1358 15 17 15 15 17 0.25 0.153 1.63 TH01 8 8 8 9.3 0.5 0.208 2.4 D13S317 12 11 12 11 1 0.246 4.06 D16S539 9 11 9 11 9 11 0.5 0.254 1.97 TPOX 8 8 8 1 0.362 2.76 D18S51 14 17 16 17 12 16 0.25 0.0832 3 D5S818 11 13 11 12 12 13 0.25 0.183 1.37 FGA 25 22 25 22 24 0.5 0.217 2.31

cc: John J Fitzmorton Patricia M. Cavenaugh Office of the District Attorney 1422 N. Hampshire St. Walden, Ohio Walden, Ohio

Below is the laboratory-internal version, with some exclusions.
The headings, footings, and choice of columns are user-configurable.

Tested man: (C) Eltinge, Julian^Who?   24-9876      Case 171
Mother:     (C) Herbert, Mathilda 24-1010      March 3, 1997 10:36
Child:          Bicious, Biddney  24-9988

SUMMARY: Exclusion Hp 6-PGD FILING CODES: F RIV rE fH mH - t13 (PATER ver 3.1.1) Excluding systems with an inconsistency -- Paternity Index = 572; Probability of paternity = 0.998 (at 50% prior); Probability of Exclusion (given mother and child) = 99.9925%

     T E S T         OBSERVED PHENOTYPES          CALCULATION OF PATERNITY INDEX  
                                     Tested     Paternity   Nonpaternity    Ratio    Random Man
                 Mother    Child     Man        Assumed (X) Assumed (Y)     (X/Y)    Eligible  

Red Cell Antigens
    ABO          A1        A2        A          0.0813      0.0556          1.464    1
    Rh           DCcE      DCcE      DCcEe      0.2481      0.0778          3.19     0.2891
    MNSs         N         MN        M          1           0.562           1.779    0.808
    Duffy        a+b-      a+b+      a+b+       0.479       0.557           0.861    0.824

Serum Proteins
    Gc           1f-2      1f-2      1s-1f      0.25        0.215           1.163    0.675
    Hp           2         2         1        Inconsistent  0.577                    0.821

Red Cell Enzymes
    AcP          AC        BC        AB         0.25        0.3057          0.818    0.849
    6-PGD        A         A         C        Inconsistent  0.982                    1
    ADA          2-1       2-1       2-1        0.5         0.5             1.001    1
    PGM          1-        1-        1          0.1905      0.144           1.323    0.942

HLA
    A locus      2,11      2,11      2,32       0.01395     0.00457         3.053    0.0666
    B locus      14,21     14,21     14,40

DNA Probes (bp)
    pS194/D7S104 5740      5740      5740       0.5         0.1766          2.831    0.322
        Pst I    6990      6990      6990

    TBQ7/D10S28  1230      1230      1780       0.25        0.034           7.35     0.0337
        Hae III  950       1450      1450

The HLA recombination rate is taken as 0.01. However, using 0 recombination in HLA X/Y=2.911 and P{C|M,M}=0.5. B21=(21,49,W50) B40=(40,W41,W47,W48,W60,W61)

cc:
       John J Fitzmorton                     Patricia M. Cavenaugh
       Office of the District Attorney       1422 N. Hampshire St.
       Walden, Ohio                          Walden, Ohio

Effect of prior probability on the likelihood of paternity:
  prior probability (%)         10     20     30     40     50     60     70     80     90
  likelihood of paternity (%)  98.5   99.3   99.6   99.7   99.8   99.9   99.93  99.96  99.98

                   Avuncular and Incest Indices
   Degree (0=alleged father or parthenogenesis, 1=uncle, etc.) of
   relation      0      1      2      3      4
Paternal         0     15.44   6.87   3.2    1.913
Maternal         0     39.3   51.5   25.39  11.16

On the basis of the genetic observations listed above (that are consistent with paternity) Julian Eltinge would be 572 times as likely to father Biddney Bicious as would a random man of similar ethnic background.

Sample Frequency and Detail Worksheet from PATER

Below are examples of some advanced features of PATER. With the Detail Worksheet the program shows the details of its serological calculation, which lets the user trace the computation process and be sure that it is correct and correctly understood.



ABO Frequency tables in use 1991/3/20 11:20
	Caucasian	Hispanic	Black	Asian
O	0.664	0.812	0.707	0.584
B	0.074	0.056	0.127	0.171
A2	0.066	0.021	0.041	0.006
A1	0.196	0.111	0.125	0.239

DETAIL calculation worksheet ****** ABO

ABO    Computation of X=P{C|M,tested man is father} = 0.05116
   Mother: A1   Child: A2   Tested man: A
                      Paternal genes
                        A2     A1     O      A2     A1
               Sperm=   O      O      A2     A2     A2
       Pat frequency= 0.0736 0.3888 0.0736 0.0019 0.0101
Maternal genotype     Likelihood of A2 phenotype:
       Ovum   M freq
A1     O      0.4362                 0.0321 0.0008 0.0044
A1     A2     0.0253   0.0019 0.0098 0.0019       0.0003

ABO        Computation of Y=P{C|M,random man} = 0.01754
   Mother: A1   Child: A2
                      Paternal genes
               Sperm=   O      A2     B      A1
       Pat frequency= 0.5840 0.0060
Maternal genotype     Likelihood of A2 phenotype:
       Ovum   M freq
A1     A2     0.0253   0.0148 0.0002
A1     O      0.4362          0.0026