| Sabbatical
Immigration Genotyper input Year 2000 compliance | |
| other newsletters | |
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| Downloads | download DNA·VIEW version 22.09
download PATER version 12.05 |
I am excited at the prospect of collaborating with such an active
and august group, notwithstanding that Jeffreys stipulated as a
condition for my coming that I will not do any "wet work." I hope
that with computer modeling work, and occasional statistics and mathematics, to be helpful on various projects.
"Immigration" update
The previous newsletter announced a new Paternity
Case feature,
Immigration,
which is a sort of automatic
version of Kinship. The first version had several
limitations, compared to the detailed control and
options that are available using Kinship. With the
latest version, most of those limitations have been
removed. For example, the Shrink match rules option
works properly in conjunction with Immigration, which
gives the user some control over the matching deci
sions (i.e. the genotype calls) that Immigration makes.
Silent alleles work correctly. Amelogenin is ignored
an adequate approach. Download
DNA2209.EXE
and see.
Genotyper (and Genomyx) import
... are new features of the Import command. The input file format
(slightly different for the two cases), is a tab-delimited ASCII file
with one row per person, and multiple columns representing a
multi-locus genotype (allele notation repeat numbers or allele letter
names).
Among the features supported are quality control (i.e. K562) size checking, just the way it works with Read.
The path chosen is to analyze it (to an extent) for what it is. The Paternity case analysis of trio/duo families now checks the amelogenin pattern based on the purported sex of the parents. The Immigration program is not so clever, but it does skip over amelogenin without (mis)analysis.
For purposes of the above features, amelogenin is identified to the program by the selection of a 2 code (X, Y allele names) in the PCR parameter "notation style".